Pharmacokinetic and clinical effects of two bupivacaine concentrations on axillary brachial plexus block

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[Pharmacokinetic and clinical effects of two bupivacaine concentrations on axillary brachial plexus block].

INTRODUCTION The risk of systemic bupivacaine toxicity is a persistent problem, which makes its pharmacokinetic study fundamental for regional anesthesia safety. There is little evidence of its influence on plasma peak at different concentrations. The present study compares two bupivacaine concentrations to establish how the concentration affects this drug plasma peak in axillary brachial plexu...

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Axillary Brachial Plexus Block

The axillary approach to brachial plexus blockade provides satisfactory anaesthesia for elbow, forearm, and hand surgery and also provides reliable cutaneous anaesthesia of the inner upper arm including the medial cutaneous nerve of arm and intercostobrachial nerve, areas often missed with other approaches. In addition, the axillary approach remains the safest of the four main options, as it do...

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Plasma concentrations of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block.

An interscalene brachial plexus block was performed via a catheter with 20-28 ml of 0.75% bupivacaine plus adrenaline for surgery of the shoulder region in 12 patients. Constant infusion of 0.25% bupivacaine 0.25 mg kg-1 h-1 was continued for 24 h. During surgery light general anaesthesia, without analgesics, was maintained. Plasma concentrations of total and unbound (free fraction) bupivacaine...

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Axillary brachial plexus block: method of choice?

The first brachial plexus block is said to have been performed by William Halsted in 1884 [32], soon after Roller [13] had demonstrated the local anaesthetic properties of cocaine. He injected the drug under direct vision, after exposing the plexus using infiltration anaesthesia. The first percutaneous blocks were performed independently in 1911 by Hirschel [11] and Kulenkampff [14], using the ...

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Ultrasound guided axillary brachial plexus block.

The axillary brachial plexus block is the most widely performed upper limb block. It is relatively simple to perform and one of the safest approaches to brachial plexus block. With the advent of ultrasound technology, there is a marked improvement in the success rate of the axillary block. This review will focus on the technique of ultrasound guided axillary brachial plexus block.

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ژورنال

عنوان ژورنال: Brazilian Journal of Anesthesiology (English Edition)

سال: 2018

ISSN: 0104-0014

DOI: 10.1016/j.bjane.2017.09.007